The Natural Products Journal Synthesis and Endothelin Receptor Binding Affinity of a Novel Class of 2-Substituted-4-aryl-3-quinolinecarboxylic Acid Derivatives Protein & Peptide Letters Chemical Constituents and Biological Significance of the Genus Ilex (Aquifoliaceae) National Institute of Pharmaceutical Education and Research (NIPER) – Ahmedabad, Department of Pharmaceutics, Opposite Air Force Station Palaj, Gandhinagar, Gujarat 382355,IndiaĪbstract: Background: Nifedipine is a potential therapeutic agent for the treatment of cardiovascularĪn Unusual Case of Reversible Empty SellaĮndocrine, Metabolic & Immune Disorders - Drug Targets Review of Evidence and Perspectives of Flavonoids on Metabolic Syndrome and Neurodegenerative Disease.Title:Microsponge Embedded Tablets for Sustained Delivery of NifedipineĪuthor(s): Rahul Maheshwari, Piyoosh Sharma, Muktika Tekade, Umesh Atneriya, Kamal Dua, Philp M. Nifedipine microsponges, sustained release. Keywords: Cardiovascular diseases, dissolution, drug loading, microsponge drug delivery, microsponge entrapped tablet, Over a period of 90 days at 40☌ and 75% RH.Ĭonclusion: The microsponge tablet delivery system was found to be superior concerning the therapeuticĪdvantage as well as manufacturing feasibility of nifedipine. Further, stabilityĪnalysis revealed good drug retention of loaded nifedipine as well as consistent in vitro release pattern Among tablet formulations,īatch composed of 48% of MF-3, 30% of MCC, 20 % of starch and 2 % of talc (TF-33), showedĩ2.73 ± 2.19 % drug release during 24 hr in vitro release study in comparison to other batches includingĬommercial formulation which was found to be released completely in 20 hr. The transformation from the Old Babylonian to late Sumerian. The equation between qerbtu environs, district and -tm is well attested. In manuscript i 2 I see: -ge-tm -bal-bal kalam-ma sg ba-ab-du 11 // qer-b-e-tum u-bal-kit-ma mta uta ispun. (10-50 %) of microcrystalline cellulose and starch as additives. In manuscript i 2 my collation confirms our tablet. Hausner ratio 1.15 ± 0.2, % compressibility 15.28 ± 0.5% and higher % drug content (80 ± 1.9 %).ĭifferent batches of tablets were then formulated incorporating MF-3 microsponges and different proportions
Results: The microsponges with molar ratio 1:3 (formulation code: MF-3) found optimized as revealedīy analyzing surface morphology, better powder flow properties (angle of repose 28.80 ± 0.9, Polymer (1:1, 1:2 and 1:3 % molar ratio) using emulsion solvent diffusion technique.
Method: Preparations of microsponges were carried out using different compositions of nifedipine and Objective: To address the problem, we first prepared nifedipine loaded sustained release microspongesĪnd then formulated tablets for effective clinical application and patient compliance. Background: Nifedipine is a potential therapeutic agent for the treatment of cardiovascularĭisturbances, although it suffers from short half-life (t1/2, 2 hr).
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